人參與Warfarin交互作用文獻回顧

Literature Review of the Interaction between Ginseng and Warfarin

陳威傑(Wei-Chieh Chen) ； 莊筱梅(Hsiao-Mei Chuang) ； 陳昱瑋(Yu-Wei Chen) ； 許航甄(Hang-Chen Hsu) ； 蔡嘉一(Chia-I Tsai)

《中醫藥研究論叢》 21卷1期 (2018/03) Pp. 51-56

https://doi.org/10.6516/TJTCM.201803_21(1).0005

摘要

在現代醫學環境中，中藥與西藥彼此間交互作用逐漸受到重視。人參是中醫在臨床使用上很重要的藥物，常被應用在於體質屬於心肺脾虛的族群上，但卻被發現可能與抗凝血用藥產生交互作用。這樣交互作用下可能會產生危及生命的風險，因此人參與Warfarin交互作用是值得進一步探討。回顧國內外文獻，發現以中草藥而言，人參是最被熱烈討論在與Warfarin產生交互作用，然而在過去文獻研究上，人參與Warfarin交互作用充滿衝突結果，深入分析與探討可以歸結出幾個重點給同道參考。對於使用Warfarin的族群，人參劑量、服用人參週數以及體質因素是產生交互作用的重要關鍵。期許在未來上可以做出更貼近臨床事實的研究，以進一步釐清問題所在。

關鍵字

人參 ； Warfarin ； 藥物交互作用

並列摘要

In modern medical environment, the awareness of the interaction between traditional Chinese medicine and western medicine has been gradually raise. Commonly used in clinical practice, Ginseng is an important Chinese herb, and is applied to patients with qi deficiency of heart, lung and spleen. However, it's found to have an interaction with anticoagulant drugs, which may cause life-threatening risks. As a result, it is worth further exploring the interaction between use of Ginseng and Warfarin. Of the reviews of domestic and international literatures, Ginseng has been the most commonly cited Chinese herb in terms of the interaction with use of Warfarin. However, the effect of Ginseng on Warfarin has been reported with abundant conflicting results according to the past literature research. After our review and discussion, we can conclude several points for physicians as reference. The key factor of the interaction between Ginseng and Warfarin lies in the dose and time length of use of Ginseng and individual constitutional factors. To sum up, advanced clinical facts of research will be expected to further clarify the problem.

並列關鍵字

Ginseng ； warfarin ； drug interaction

參考文獻

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