Hypertrophy of the prostate is a common clinical disease in elder patients of Chinese medicine. Common symptoms of hypertrophy of the prostate are urinary frequency, urinary urgency, nocturia, residual urine and urinary incontinence. The patient in this case report is an 81-year-old male with hypertrophy of the prostate for decades. In recent 3-4 years, the symptoms of urinary frequency, urinary urgency and nocturia were exacerbated and lead to reduced quality of life. After oral Chinese medicine coupled with acupuncture treatment in the outpatient department, the frequency of urine was improved from 20 times to 8-10 times per day, the symptom of urinary urgency slowed down, urinary incontinence was almost non-occurring, and nocturia was reduced from 5 times to 2 times per night. The quality of life has been improved dramatically. Our report shows that acupuncture treatment combined with traditional Chinese medicine can effectively improve the symptoms of urinary frequency, urinary urgency, nocturia and prostate hypertrophy in elderly patients.