Amino acid dosing in parenteral nutrition for very low birth weight preterm neonates: an outcome assessment

本研究旨在马来西亚当地一家医院进行回顾性研究，探讨极低体重儿肠外营养（PN）氨基酸（AA）对体格改变的影响。在2012年间，从新生儿病房登记的新生儿记录中按规定筛选出合格的新生儿，一共有199名早产儿接受PN支持，其中100名符合纳入标准。早产儿第一天肠外营养AA摄入量的中位数是2.00（＜28周组）、1.00（28-31周组）和0.75（＞31周组）。与其他两组相比，＜28周组早产儿更容易在较早的时间接受较高的初始AA剂量。本研究还发现PN管理的第一天AA的使用剂量没有统计学差异，而且受试者营养参数的显著差异并没有导致生理结果的差异。本研究确定了在当地医院环境下提供PN的时间，很有可能目前的营养做法不足以达到早产儿标准生长建议。由于增长限制的发病率会影响婴儿生长发育，我们的研究结果呼吁需要优化AA和热量的摄入量。为了改善患者的治疗效果，需要对这家医院当前的PN处方进行审查。

關鍵字

出生体重；营养需求；生长发育；营养支持；营养治疗

並列摘要

This study aimed to investigate the effects of parenteral nutrition (PN) administration of amino acids (AA) on physical changes among very low birth weight infants in a local hospital setting in Malaysia. A retrospective study was carried out at a hospital in Malaysia. Records of neonates prescribed PN in the neonatal unit in 2012 were screened for eligibility. A total of 199 premature neonates received PN support in the year 2012 and, of these, 100 fulfilled the inclusion criteria. The median value of AA intake on the first day of PN was 2.00 (＜28 weeks group); 1.00 (28-31 weeks group) and 0.75 (＞31 weeks group). Neonates in the ＜28 weeks group were more likely to receive AA at an earlier time and higher initial dose compared with the other age groups. The study also found that there was no statistically significant difference in the dose of AA on the first day of PN administration and that the significant variations in nutritional parameters among the subjects did not lead to differences in physical outcomes. This study identified that when PN is provided in the local hospital setting, it is likely that the current nutritional practices are inadequate to achieve the standard growth recommendations. Our findings call for a need to optimize AA and calorie intake since growth restriction is a morbidity which will affect the infants’ growth and development. Current prescriptions for PN in this hospital need to be reviewed in order to improve patient outcomes.

並列關鍵字

birth weight ； nutritional requirements ； growth and development ； nutritional support ； nutritional therapy

國際替代計量

Amino acid dosing in parenteral nutrition for very low birth weight preterm neonates: an outcome assessment

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