American ginseng (Panax quinquefolium, Araliaceac), which is native to North America, is one of the most widely used medicinal herbs in the world. Ginsenosides in American ginseng include ginsenosides Rb1, Rb2, Rc, Rd, Re, Rg1, Rg3 and Rh2. American ginseng demonstrates a wide variety of pharmacological effects to reduce postprandial blood glucose, protect nerve system, boost the immune system, prevent acute respiratory illness, anti-oxidative, and anti-inflammation. American ginseng is also used clinically to treat diabetes and prevent acute respiratory illness in many years. In the review studies indicated that ginsenosides of American ginseng can inhibit digestive enzyme activities, promote ulcer heal, decrease inflammation response, and reduce DNA damage in colonic epithelial cell. Consequently, American ginseng may have effective to improve gastrointestinal tract damage induced by exercise.