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Effects of Transscleral Cryotherapy and Diathermy on the Ocular Growth in Rabbits

冷凍療法和電氣燒灼術對兔子眼球生長之影響

Abstracts


為了研究冷凍療法及電氣燒灼術對眼球生長之影響。我們研究24隻紐西蘭白兔,12隻施行冷凍療法,12隻施行電氣燒灼術。手術施行於三至四週大白兔之右眼,左眼當做對照組。手術均施行於赤道部前面360°,避開長睫動脈及神經。眼球各徑長(包括前房深度、水晶體厚度、眼軸長度)及眼壓在手術前及術後每個月追踪檢查,直至三個月大為止。結果發現電氣燒灼術之眼球明顯地比對照眼為小。而冷凍療法也比正常對照眼為小,但只有在第二個月是有意義之差別。前房深度、水晶體厚度、眼壓在手術眼及對照眼並無有意義之差別。由病理組織切片,我們發現電氣燒灼術後之鞏膜很明顯地比臨近的正常鞏膜為薄,而冷凍療法則並無差異。所以,週邊網膜破壞術(冷凍療法及電氣燒灼術)能控制眼球之生長主要可能經由網膜和鞏膜的作用。

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Parallel abstracts


Purpose. To determine the effect of transscleral cryotherapy of diathermy on anterior part of eyeball on ocular growth. Methods. Twenty-four New Zealand White rabbits were used. Transscleral cryotherapy (n=12) or diathermy (n=12) was performed on the right eye of 3-4 weeks old rabbits, the left eye was left untreated for control. Transcleral cryotherapy and diathermy were applied 360° to the retina anterior to the equator, except in areas where the long ciliary arteries and nerves were located. Biometric ocular dimensions (anterior chamber depth, lens thickness, axial length) and intraocular pressure. (IOP) were measured before and then every month until 3 months later. Results. The ocular size of diathermy-treated eyes was significantly smaller than the untreated control eyes from first to third month later (p<0.01). As well, the size of cryotherapy-treated eye was also smaller than control eye, but it was not significantly different on the first and third month (p=0.17). The anterior chamber depth, lens thickness and IOP were not significantly different between treated and untreated eyes. Histological evidence showed the sclera of diathermy area was thinner than the normal sclera, but the cryotherapy was not. Conclusions. The mechanisms of peripheral retinal ablation controlling ocular growth may through both of retinal and scleral effects.

Parallel keywords

Cryotherapy diathermy ocular growth sclera

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