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Hepatoprotective Effect of Ethanolic Leave Extract of Moringa oleifera on the Histology of Paracetamol Induced Liver Damage in Wistar Rats

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This study was designed to evaluate the Hepatoprotective effect of Ethanolic leave Extract of Moringo Oleifera on the Histology of the liver of wistar rats. Fifteen (15) female adult wistar rats were divided into three (3) groups. Group I was the Control group that received distilled water only, group II was the negative control that received 1 g/kg of paracetamol on the 10^(th) day, and group III received 500 mg/kg of the extract for duration of ten (10) days. Group III was pre-treated with 500 mg/kg of the ethanolic leave extract of Moringa oleifera before inducing the liver damage on the 10^(th) day with 1 g/kg of paracetamol. Twelve (12) h after administration, the rats were sacrificed and the liver was fixed immediately in Formalin. The liver tissues was processed and stained in Haematoxylin and Eosin (H&E).The histological observations showed that the leave extract of Moringa oleifera was hepatoprotective.

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