This article is to describe one of the core areas of Pivotal Response Treatment (PRT) - responsivity to multiple cues. The PRT intervention targets on four pivotal areas of children's development, motivation, responsivity to multiple cues, social initiations, and self-management. The teaching approaches and examples on the area of "responsivity to multiple cues" are provided. At last, the benefits of teaching "responsivity to multiple cue" of PRT are summarized for educators. The teaching examples of PRT-responsivity to multiple cue are also addressed.