新生兒、兒童、成人及各種血液病兒童血清轉鐵素和鐵蛋白濃度之測定

The Serum Levels of Transferrin and Ferritin in Term and Preterm Newborn Infants, Children, Adults, and in Children with Some Hematologic Disorders

鄭琇芳(Shiow-Fang Cheng) ； 劉文章(Wen-Jang Liu) ； 黃德揚(The-Yang Huang) ； 陳添享(Tien-Siang Chen)

《Acta Paediatrica Sinica》 26卷1期 (1985/02) Pp. 94-99

摘要

Serum levels of transferrin and ferritin were measured in normal full term and in premature babies, in preschool children (2-6 years old), primary school children, in normal female and male adults and in children with, various types of blood disease. Blood samples were collected by heel prick. The serum concentration of transferrin was determined by radioimmunodiffusion and of ferritin, by enzyme immunoassay.
The results were as follows:
(A) Mean levels and standard deviation of serum transferrin were 187±24.2mg/dl in full-term newborn babies; 134.0±58.3mg/dl in premature babies; 304.5±69.5mg/dl in preschool children;. 289.4±41.2mg/dl in school children; 272.7±44.5mg/dl in adults; 175.0±24.8mg/dl in children with thalassemia major; and 400.0±31.5mg/dl in children with iron deficiency anemia. The mean serum levels of transferrin for full-term newborn babies and premature babies were lower than those of adults and children (P＜0.001). The serum levels in thalassemia children, were also, lower than those of normal children (P＜0.001).
(B) The geometric means of serum ferritin concentration were 250.6ng/ml in newborn babies; 147.9ng/ml in premature babies; 29.1ng/ml in preschool children 57.7ng/ml in primary school children; 144.2ng/ml in male adults; 59.6ng/ml in female adults; 1840.8ng/ml in children with thalassemia major; 186.2ng/ml in children with malignant blood diseases; and 63.1ng/ml in children with idiopathic thrombocytopenic purpura. Three of the children had iron deficiency anemia lower than l2ng/ml.
Serum concentration of transferrin and ferritin has been used clinically for the diagnosis and follow-up evaluation of subjects with iron deficiency and iron overload. Measurement of transferrin and ferritin may be used for the screening of iron status in large populations.

並列摘要

Serum levels of transferrin and ferritin were measured in normal full term and in premature babies, in preschool children (2-6 years old), primary school children, in normal female and male adults and in children with, various types of blood disease. Blood samples were collected by heel prick. The serum concentration of transferrin was determined by radioimmunodiffusion and of ferritin, by enzyme immunoassay.
The results were as follows:
(A) Mean levels and standard deviation of serum transferrin were 187±24.2mg/dl in full-term newborn babies; 134.0±58.3mg/dl in premature babies; 304.5±69.5mg/dl in preschool children;. 289.4±41.2mg/dl in school children; 272.7±44.5mg/dl in adults; 175.0±24.8mg/dl in children with thalassemia major; and 400.0±31.5mg/dl in children with iron deficiency anemia. The mean serum levels of transferrin for full-term newborn babies and premature babies were lower than those of adults and children (P＜0.001). The serum levels in thalassemia children, were also, lower than those of normal children (P＜0.001).
(B) The geometric means of serum ferritin concentration were 250.6ng/ml in newborn babies; 147.9ng/ml in premature babies; 29.1ng/ml in preschool children 57.7ng/ml in primary school children; 144.2ng/ml in male adults; 59.6ng/ml in female adults; 1840.8ng/ml in children with thalassemia major; 186.2ng/ml in children with malignant blood diseases; and 63.1ng/ml in children with idiopathic thrombocytopenic purpura. Three of the children had iron deficiency anemia lower than l2ng/ml.
Serum concentration of transferrin and ferritin has been used clinically for the diagnosis and follow-up evaluation of subjects with iron deficiency and iron overload. Measurement of transferrin and ferritin may be used for the screening of iron status in large populations.

並列關鍵字

transferring ； ferritin