Nesidioblastosis引起新生兒持續性低血糖―一病例報告―

Intractable Neonatal Hypoglycemia Due to Nesidioblastosis-A Case Report-

曾繁英(Fan-Ing Tzeng) ； 王榮文(Jung-Wen Wang) ； 林哲男(Jer-Nan Lin) ； 龐柳川(Leou-Chung Pang) ； 蘇益仁(Ih-Jen Su)

《Acta Paediatrica Sinica》 26卷4期 (1985/08) Pp. 332-337

摘要

此病例是一新生兒發生持續性的低血糖，並且在低血糖之同時測得偏高的血胰鳥素值而在尿液及血液中並未出現酮體。在低血糖時接受升糖素注射試驗，血糖上升值達大於30mg%，經過內科治療包括蔔萄糖注射，Hydrocortisone, Glucagon, Diazoxide，仍然會間歇的出現低血糖，因此接受百分之九十五的胰髒切除手術。病理報告證實為Nesidioblastosis，唯手術後血糖偏高，目前尚須胰鳥素的治療。

並列摘要

A case of nesidioblastosis is reported. The female newborn developed severe persistent hypoglycemia since three days of age. There were inappropriately high plasma insulin concentrations for the levels of glucose but no ketone body existed in urine or blood during hypoglycemia. The rise in plasma glucose in response to glucagon injection during hypoglycemia was more than 30 mg%. Medical treatments (glucose infusion, hydrocortisone, glucagon, diazoxide) were ineffective for controlling hypoglycemia. Therefore, she received 95% pancreatectomy at 25 days of age. The pathological examination of pancreas revealed increased number of insulin producing cells, which were proved by hematoxylin eosin stains and peroxidase antiimmunoperoxidase methods. After pancreatectomy, she required insulin to control hypoglycemia. Growth and development follow-up at three-months of age were above the fiftieth percentile.

並列關鍵字

hypoglycemia ； hyperinsulinism ； nesidioblastosis