The Use of Amniotic Fluid Shake Tests, L/S Ratio and Creatinine Concentration in the Evaluation of Fetal Maturity and Risk of Neonatal Respiratory Distress Syndrome

羊水泡沬試驗L/S比率及肌酸酐濃度對胎兒成熟度及預估新生兒呼吸窘迫症發生之評估

曹龍彥(Lon-Yen Tsao) ； 廖美芬(Mei-Fen Liao) ； 楊漢銘(Han-Ming Yang) ； 施木青(Mu-Ching Shih)

《Acta Paediatrica Sinica》 26卷5期 (1985/10) Pp. 411-419

摘要

A total of 65 shake tests (Clements and FS-50 tests), 65 L/S ratio, 58 creatinine concentrations were carried out on amniotic fluid specimens. The results were analyzed in relation to gestational age and neonatal respiratory distress syndrome. This study revealed that: (1) Clements tests, FS-50 test, L/S ratio, and creatinine concentration vs. gestational age showed a good positive linear relationship, with correlation coefficients of 0.510, 0.443, 0.703, 0.617, respectively. (2) Clements tests (＜2+vs.≥2+), FS-50 test (＜2 vs. ≥2+), L/S ratio (＜2.0 vs. ≥2+), creatinine concentration (＜1.5mg! 100 ml vs. ≥1.5 mg/100 ml) showed statistically significant differences in occurrence of neonatal respiratory distress syndrome with P value ＜ 0.001. (3) The sensitivity, specificity, predictive value positive, predictive value negative of these tests and their combinations were also calculated. All of these amniotic fluid indices of fetal maturity were better predictors of maturity than of immaturity. (4) Statistical relationships of shake tests vs. L/S ratio and amniotic fluid creatinine concentration vs. L/S ratio showed fair to good correlation, it was concluded that amniotic fluid analysis with shake tests, L/S ratio, and creatinine concentration are valuable in assessing fetal maturity and in predicting the likelihood of neonatal RDS. The rapid tests (shake tests and creatinine concentration) can be widely used in emergency situations or in those hospitals where L/S ratio and phosphatidylglycerol, phosphatidylinositol determinations are not available.

並列摘要

A total of 65 shake tests (Clements and FS-50 tests), 65 L/S ratio, 58 creatinine concentrations were carried out on amniotic fluid specimens. The results were analyzed in relation to gestational age and neonatal respiratory distress syndrome. This study revealed that: (1) Clements tests, FS-50 test, L/S ratio, and creatinine concentration vs. gestational age showed a good positive linear relationship, with correlation coefficients of 0.510, 0.443, 0.703, 0.617, respectively. (2) Clements tests (＜2+vs.≥2+), FS-50 test (＜2 vs. ≥2+), L/S ratio (＜2.0 vs. ≥2+), creatinine concentration (＜1.5mg! 100 ml vs. ≥1.5 mg/100 ml) showed statistically significant differences in occurrence of neonatal respiratory distress syndrome with P value ＜ 0.001. (3) The sensitivity, specificity, predictive value positive, predictive value negative of these tests and their combinations were also calculated. All of these amniotic fluid indices of fetal maturity were better predictors of maturity than of immaturity. (4) Statistical relationships of shake tests vs. L/S ratio and amniotic fluid creatinine concentration vs. L/S ratio showed fair to good correlation, it was concluded that amniotic fluid analysis with shake tests, L/S ratio, and creatinine concentration are valuable in assessing fetal maturity and in predicting the likelihood of neonatal RDS. The rapid tests (shake tests and creatinine concentration) can be widely used in emergency situations or in those hospitals where L/S ratio and phosphatidylglycerol, phosphatidylinositol determinations are not available.

並列關鍵字

amniotic fluid ； shake tests ； creatinine ； lecithin/sphingomyelin (L/S) ratio