Increased Erythrocyte Adenosine Deaminase Activity in Asthmatic Children

氣喘兒童紅血球ADENOSINE DEAMINASE活性之上昇

黃焜璋(Kung-Chang Hwang) ； 王志堯(Jiu-Yao Wang) ； 謝貴雄(Kue-Hsiung Hsieh)

《Acta Paediatrica Sinica》 31卷2期 (1990/04) Pp. 76-80

摘要

Erythrocyte adenosine deaminase (ADA) activity was measured in 19 newly-diagnosed and 20 hyposensitized asthmatic children, as well as 11 age-matched normal children. ADA activity was determined by adenosine catalyzed reactions. The results showed:1) The mean value of ADA activity was 72.9±30.4μmole/min/unit OD54lnm in newly- diagnosed asthmatics; 52.7±37.9μmole/min/unit OD541nm in hyposensitized patients and 39.5±26.7μmole/min/unit OD54lnm in normal controls; 2) there was significant elevation in erythrocyte ADA activity in newly-diagnosed asthmatic patients as compared to normal controls (P＜0.05), but there was no difference between newly-diagnosed and hyposensitized patients (P＞0.05), and between hyposensitized patients and normal controls (P＞0.2). The mechanism and possible clinical implication of increasing erythrocyte ADA activity in newly-diagnosed asthmatic patients are discussed.

並列摘要

Erythrocyte adenosine deaminase (ADA) activity was measured in 19 newly-diagnosed and 20 hyposensitized asthmatic children, as well as 11 age-matched normal children. ADA activity was determined by adenosine catalyzed reactions. The results showed:1) The mean value of ADA activity was 72.9±30.4μmole/min/unit OD54lnm in newly- diagnosed asthmatics; 52.7±37.9μmole/min/unit OD541nm in hyposensitized patients and 39.5±26.7μmole/min/unit OD54lnm in normal controls; 2) there was significant elevation in erythrocyte ADA activity in newly-diagnosed asthmatic patients as compared to normal controls (P＜0.05), but there was no difference between newly-diagnosed and hyposensitized patients (P＞0.05), and between hyposensitized patients and normal controls (P＞0.2). The mechanism and possible clinical implication of increasing erythrocyte ADA activity in newly-diagnosed asthmatic patients are discussed.

並列關鍵字

erythrocyte ADA activity ； asthmatic children