The Effect of Povidone-iodine on Thyroid Function of Neonates with Different Birth Sizes

碘液對不同出生體重新生兒甲狀腺功能的影響

鄭玫枝(Mei-Jy Jeng) ； 林清淵(Ching-Yuang Lin) ； 宋文舉(Wen-Jue Soong) ； 蕭廣仁(Kwang-Jen Hsiao) ； 黃碧桃(Be-Tau Hwang) ； 蔣思慧(Szu-Hui Chiang)

《Acta Paediatrica Sinica》 39卷6期 (1998/12) Pp. 371-375

https://doi.org/10.7097/APS.199812.0371

摘要

碘液是醫院常用的消毒劑，以往有文獻報導碘液可經由皮膚吸收而影響甲狀腺功能。本研究目的觀察在一個高碘攝取城市中不同出生體重與懷孕週數之新生兒在使用含碘溶液後其狀腺功能之變化情形。四十四位因接受注射週邊中央靜脈導管而需使用碘液消毒之早産兒與足月兒接受足跟紮血，測定一系列之甲狀腺素，甲狀腺刺激素與肌肝酸素。結果顯示只有極低出生體重早産兒之甲狀腺刺激素在使用碘液消毒48小時後會有顯著之上昇。出生體重愈小者，其甲狀腺素愈低而肌肝酸素愈高。結論是高碘攝取區域出生之極低出生體重早産兒仍應避免使用含碘溶液作單次大面積之皮膚消毒。

關鍵字

碘液 ； 甲狀腺 ； 新生兒 ； 早産兒

並列摘要

The aim of this study was to elucidate the role of povidone-iodine (PV-I) on thyroid function of newborns with different birth sizes in a high iodine-intake city. Serial measurements of serum thyroxine (T4) and thyrotropin (TSH) levels were done in 44 newborns locally treated with 10% PV-I for insertion of percutaneous central venous catheters. The results showed that the thyroid function was influenced prominently in very-low-birth weight (VLBW) babies. TSH went significantly higher after application of PV-I for 48 hours in VLBW babies. The smaller the babies were, the lower the T4 at birth and thereafter. In conclusion, PV-I is suggested to be avoided for single application on a wide skin surface in VLBW babies, even in an area with high iodine-intake population.

並列關鍵字

povidone-iodine ； thyroid ； neonate ； premature infant