Studies on the Production of Some Important Secondary Metabolites from Medicinal Plants by Plant Tissue Cultures

利用組織培養生產藥用植物重要二次代謝物之技術

Mulabagal Vanisree ； 李鎮宇(Chen-Yue Lee) ； 羅淑芳(Shu-Fung LO) ； Satish Manohar Nalawade ； 林俊義(Chien Yih Lin) ； 蔡新聲(Hsin-Sheng Tsay)

《Botanical Bulletin of Academia Sinica》 45卷1期 (2004/01) Pp. 1-22

https://doi.org/10.7016/BBAS.200401.0001

摘要

藥用植物是新藥開發最重要的資源，目前已有許多對人類健康有益的藥物，是直接由植物的二次代謝物或將此二次代謝物略加修飾之後所獲得，因此，利用組織培養生產植物有用的二次代謝物或提高二次代謝物產能的技術，最近幾十年頗受世界各國學者的重視。始自1960年代末期，三角瓶培養系統以及運用許多不同培養策略的植物細胞培養技術，即被應用於生產二次代謝物之研究。本文綜合報導過去十幾年來組織培養技術應用於藥學領域的研究概況，同時也摘要寫出作者十幾年來從事植物組織培養生產二次代謝物之心得，提供讀者參考。

關鍵字

生物轉換 ； 細胞懸浮培養 ； 毛髮狀根培養 ； 藥學 ； 二次代謝物

並列摘要

Plants are a tremendous source for the discovery of new products of medicinal value for drug development. Today several distinct chemicals derived from plants are important drugs currently used in one or more countries in the world. Many of the drugs sold today are simple synthetic modifications or copies of the naturally obtained substances. The evolving commercial importance of secondary metabolites has in recent years resulted in a great interest in secondary metabolism, particularly in the possibility of altering the production of bioactive plant metabolites by means of tissue culture technology. Plant cell culture technologies were introduced at the end of the 1960's as a possible tool for both studying and producing plant secondary metabolites. Different strategies, using an in vitro system, have been extensively studied to improve the production of plant chemicals. The focus of the present review is the application of tissue culture technology for the production of some important plant pharmaceuticals. Also, we describe the results of in vitro cultures and production of some important secondary metabolites obtained in our laboratory.

並列關鍵字

Biotransformations ； Cell suspension cultures ； Hairy root cultures ； Pharmaceuticals ； Secondary metabolites