Intermetatarsal nerve entrapment, also called Morton's neuroma, is a paroxysmal neuralgia affecting the web spaces of the toes. The disease occurs in women and is commonly correlative with constricting footwear or high-heeled shoe. The clinical symptoms include numbness of toes, prickling and tingling at food endings. The patient is an age 46 female, who suffered from tingling around the web spaces of the left foot and numbness and pain radiating to the second and the third toe for one week. She was treated with acupuncture, herbal patch and Chinese medicine. Moreover, she received health education. The result demonstrated that the patient was relieved from pain and whose overall quality of life improved thus proving to be an effective method of treatment.