- 期刊
五種農藥對大鼠子代外觀與骨骼之影響
The Effect of Five Pesticides on External and Skeletal Changes of Fetuses in Rats
摘要
以免賴得（benomyl）、貝芬替（carbendazim）、三苯醋錫（TPTA）、大滅松（dimethoate）、甲基多保淨（topsin-M）等五種本省常用農藥為供試藥劑，以胃管法投子雌鼠後，探討其可能造成子鼠外觀及其骨骼之影響。試驗結果顯示，免賴得與貝芬替兩藥劑對大鼠子代不僅造成外觀畸形（external malformation），亦造成其細部骨骼異常，其比率與劑量分別呈負與正相關反應。三苯醋錫、大滅松及甲基多保淨各葯劑對子鼠外觀與其細部骨骼均無影響。免賴得與貝芬替外觀畸形分別為露腦、裂腹與露腦、頭狀鼻、無尾、尾巴彎曲、全身浮腫、無嘴及死亡等；而二藥劑細部骨骼異常主要為頸椎數少於7、分叉弓之頸椎、多餘骨化頸椎、頸椎或頸椎中心融合、頸椎或頸椎中心發育不全、頸椎形態變異、肋骨少於13、第13肋過小、二肋骨融合、啞鈴狀之胸腰椎中心、浮肋及肋骨形狀變異。
並列摘要
This study was conducted to evaluate the relationship between Benomyl, Carbendazim, Topsin-M, Dimethoate, and TPTA administrated by gavage, and the external and skeletal changes of fetuses in rats. Results showed that Benomyl and Carbendazim could cause external malformations and skeletal malformations, anomalies, and variations, but similar changes were not found in Topsin-M, Dimethoate, and TPTA. The Carbendazim-inducing skeletal changes in rats had a dose-response relationship. The external malformations observed in Benomyl-treated fetuses induced exencephaly and gastroschisis. Exencephaly, rhinocephaly, anury, kinky or bent tail, edema, astomia, and fetal death occurred in Carbendazim-treated fetuses. The skeletal anomalies revealed in Benomyl and Carbendazim-treated rats were absence (＜ 7) of arch, bifurcated arches, extra ossification on an arch, fused arches/centers, hypoplastic arches/centers, variation in shapes/size, reduction in the number (＜ 13) of ribs, small 13th rib, fused ribs, dumbbell-shaped center, wavy and variations in shape.