- 期刊
小白鼠性成熟與皮下肉瘤－180腫瘤生長的關係
The Relationship between Sexual Maturation and Growth of the Subcutaneous Sarcoma-180Tumor
摘要
小白鼠性賀爾蒙可影響免疫反應及頜下腺表皮生長因子的合成作用。雄性素抑制免疫反應但會促進頜下線表皮生長因子合成的作用。雌性素則相反。表皮生長因子是促進腫瘤生長的生長因子之一。本實驗以成熟前後不同週齡，及成熟後切除性腺之小白鼠皮下接種肉瘤－ 180以觀察腫瘤生長情形。小白鼠性成熟前皮下種腫瘤細胞，腫瘤生長快而且沒有性別差異。成熟後接種者，則雌鼠腫瘤生長仍然快速，與未成熟者同。睪丸切除使已成熟雄性小白鼠之皮下腫瘤生長延滯，雌性小白鼠則因卵巢切除而使腫瘤生長加速。因此性腺切除使兩性之腫瘤生長相近似。
關鍵字
無資料並列摘要
The sex hormones of mice have effects on the immune response and the synthesis of epidermal growth factor(EGF). Androgen inhibits the former and enhances the later, whereas estrogen has the opposite effect. EGF is one of the tumor growth factors. In the present study, mice before or after sexual maturation, or gonadectomized adults of both sexes, were subcutaneously inoculated with sarcoma-180 tumor cells. The tumors grew rapidly, with no difference in genders before sexual maturation. However, tumor growth was rapid in adult male mice after sexual maturation, but retarded or inhibited in adult female mice. In orchidectomized male mice, tumor growth slowed down, in ovariectomized female mice, tumor growth accelerated. There was no difference in the rate of tumor growth among gonadectomized mice of either sex.
延伸閱讀
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