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Skull Metastasis of Primary Hepatoma - Case Report

肝癌之顱骨轉移-病例報告

摘要


病人為五十六歲男性,最近九個月,頭皮逐漸隆起數個腫塊,但沒有發現任何神經症狀,腦部電腦斷層掃描顯示顱骨上有數個蝕骨性腫瘤,壓迫腦組織,經手術做病理切片檢查及腹部超音波掃描,證實為轉移性肝癌。 文獻上曾報告過九例,加上本例,共有10人,七男三女,年齡為50~65歲,平均年齡56.8歲,Alpha fetoprotein的發現率為50%(2/4)。生長部位有五個長在顱底骨,五個長在顱頂骨,顱底骨病灶常引起顱神經症狀,顱頂骨病灶則以頭痛、運動感覺障礙等症狀為主。 治療以局部放射線療法或化學療法為主,若單一顱頂骨腫瘤則可以手術切除,這十個病人之平均存活時間(mean survival time)為19個月,中間存活時間(median survival time)為9.5個月,較一般肝癌的平均存活時間(小於六個月)為長,其造成原因可能是此類病人的臨床病程較緩和。目前肝癌治療成果較以往略有進展,此類病人應有增加的趨勢,故要進一步的研究與治療(如全身性化學療法)是有必要的。

關鍵字

無資料

並列摘要


Skull metastasis of hepatoma is rare. A case of a 56 year-old man with painless masses over the skull is presented in this paper. The largest mass in the occipital area measured 10×5 cm2; skull radiographs and computed tomography (CT) of the brain revealed several skull tumors with epidural extensions. The largest mass was slmost totally excised, and metastatic hepatoma was diagnosed by a histological examination and supported by abdominal ultrasound findings. Literature in regard to hepatoma with skull metastasis is also reviewed.

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