Vesicant chemotherapy extravasations can cause the serious necrosis of skin, muscle, and tissue, resulting in excessive physical damage. Thus, preventing these extravasations is one of the fi rst priorities of patient care during chemotherapy. Prior research has indicated that the main causes of drug extravasation include the following: (1) nurses do not inform patients of the risk of extravasation or inspect skin integrity, (2) patients have insufficient knowledge of the safety of intravenous injection, and (3) nurses do not place the intravenous devices properly. Thus, nurses should provide patients and their families with appropriate information on the safety of intravenous care before administering chemotherapy. Nurses should be aware of the methods of preventing extravasations and detecting the early signs of vesicant chemotherapy extravasations. If extravasations occur nonetheless, then initiating the required procedures is crucial to minimizing the damage.