Some Psychopharmacologic and Other Drugs on the Swimming Performance of Rats

心理藥理劑及其他數種藥物對大白鼠游泳運動之影響

李鉅(R. C. Li) ； 王耀羣(Y. C. Wang)

《The Chinese Journal of Physiology》 20卷1期 (1967/06) Pp. 71-77

摘要

用大白鼠48隻，分七組，先訓練游泳4~19日，然後分別測定心理藥理劑及其他藥物共十五種，對游泳之「認清方位時間」，及「游泳時間」。自入水而猶豫未游畢全程之時間為「認清方位時間」。全程前進游泳所用時間為「游泳時間」。
在四十六次試驗中，Chlorpromazine, Amphetamine, Tranylcypromine及Phenelzine（一次）延長「認清方位時間」，而Nialamide, Imipramine, Phenelzine（一次）及DCI與Isoproterenol同用則減短之，又Chlorpromazine,5-HT,Physostigmine,Tranylcypromine,Amphetamine,Reserpine,Norepinephrine,Isoproterenol（單獨用或與DCI同用）及Imipramine兩次則延長游泳時間而一次則減短之。以上差別，皆具統計上意義。

並列摘要

Li, R. C. and Y. C. Wang. Some psychopharmacologic and other drugs on the swimming performance of rats. Chinese J.Physiol.,20(1):71-77,1967.--The swimming performance of albino rats under several psychopharmacologic, central, and autonomic agents was assessed in terms of two definable parameters. ”Orientation” time(Ⅰ)was interval between immersion and starting to swim the whole length of water ahead and swimming(orthodromic)time(Ⅱ)was time actually taken to swim 16 feet of water alley to reach landing ladder.Ⅰwas significantly increased by chlorpromazine(CPZ), amphetamine, tranylcypromine and phenelzine(1 experiment)and significantly decreased by nialamide, imipramine, phenelzine(1 experiment) and isoproterenol following dichloroisoproterenol (DCI), though not by isoproterenol alone..Ⅱ was significantly increased by CPZ, 5-HT, tranylcypromine, amphetamine, reserpine, norepinephrine, isoproterenolwith or without DCI, imipramine(2 experiments, female rats)andphysostigmine, but significantly decreased by imipramine(1 experiment, male rats).These results indicate that Ⅰ was more specifically affected by psychopharmacologic agents than by drugs of other types, while Ⅱ was affected by diverse types of drugs, psychopharmacologic and other.