- 期刊
Immunoreactive GnRH and TRH in the Peripheral Blood of Ovariectomized and Ovariectomized-Thyroidectomized Rats: Relation to LH, TSH and PRL Release
去卵巢鼠及同時去卵巢和甲狀腺鼠血清性釋素及甲釋素濃度之變化
摘要
本研究旨在探討去卵巢鼠及同時去卵巢和甲狀腺鼠血清性釋素及甲釋素濃度之變化，以及其變化與血清黃體促素，甲促素和泌乳素濃度之關係。大鼠分別在手術後第50，70及90天切頭犧牲取血。正常雌鼠則分別於動情前期，動情期及動情間期犧牲取血。血清各激素之濃度均以放射免疫測定法檢測。去卵巢後，第50及第70天，血清性釋素濃度比正常鼠低，唯至第90天，則比正常鼠高2~4倍。大鼠去卵巢後，血清甲釋素濃度逐漸升高，至手術後第90天幾達正常鼠之20倍。卵巢切除後，黃體促素濃度逐漸升高，泌乳素濃度逐漸下降，甲促素濃度則不改變。同時切除甲狀腺和卵巢的大鼠與僅切除卵巢之大鼠相較，血清性釋素濃度變化無差異，甲釋素濃度則僅在第50天偏低，在第70及第90天無差異。同時切除甲狀腺的大鼠，血清泌乳素濃度比僅去卵巢鼠者更低。唯血清甲促素濃度，則因負迴饋而大幅上升。以上結果顯示，長期去卵巢，升高血清性釋素及甲釋素濃度，其變化與腦下腺分泌之黃體促素，甲促素，及泌乳素濃度並無密切之相關性。長期切除甲狀腺和卵巢對血清性釋素及甲釋素濃度之影響與僅去卵巢者相似。
關鍵字
無資料並列摘要
Pu, H.F, and P.S. Wang: Immunoreactive GnRH and TRH in the peripheral blood of ovariectomized and ovariectomized-thyroidectomized rats: Relation to LH, TSH and PRL release. Chinese J. Physiol. 30(2): 15-27, 1987. Immunoreactive gonadotropin-releasing hormone (IR-GnRH) and thyrotropin-releasing hormone (IR-TRH), luteinizing hormone (LH), thyrotropin (TSH), and prolactin (PRL) in the peripheral sera of proestrus, estrus, diestrus as well as long term ovariectomized (Ovx) and ovariectomized-thyroidectomized (Ovx-Tx) rats were measured by radioimmunoassay. Ovx and Ovx-Tx rats were decapitated on days 50, 70, and 90 following operation. The concentration of serum IR-GnRH in Ovx and Ovx-Tx rats on days 50 and 70 post-ovariectomy was lower than that in intact females. Serum IR-GnRH level in rats 90 days post-ovariectomy was increased by 2-to 4-fold as compared with intact rats. The concentration of serum IR-TRH was gradually increased in Ovx and Ovx-Tx rats from day 50 to day 90 post-ovariectomy. Thyroidectomy did not alter the concentration of serum IR-GnRH and IR-TRH in Ovx rats on days 70 and 90 post-ovariectomy. Thyroidectomy increased serum LH and TSH levels but reduced serum PRL level in Ovx rats. There is no correlation between serum IR-GnRH and LH levels as well as serum IR-TRH and TSH or PRL levels, respectively, in chronic Ovx and Ovx-Tx rats.
延伸閱讀
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