Serum Lutein and Its Dynamic Changes during Supplementation with Lutein in Chinese Subjects

中国人群血清叶黄素水平及叶黄素干预过程中的动态变化趋势

Le Ma ； Xiao-Ming Lin ； Xian-Rong Xu ； Zhi-Yong Zou ； Zi-Xin Wang ； Yang-Mu Huang ； Ying Li

《Asia Pacific Journal of Clinical Nutrition》 18卷3期 (2009/09) Pp. 318-325

https://doi.org/10.6133/apjcn.2009.18.3.03

摘要

观察性研究结果显示摄取含叶黄素的食品与慢性疾病的患病危险性呈负相关。但是许多研究的结果并不一致，这可能归因于各种混杂因素影响血清叶黄素浓度。本研究目的在于确定影响中国健康人群叶黄素水平的因素，并观察叶黄素干预过程中血清叶黄素的变化趋势。在基线调查后，37名健康受试者被随机分配到6 mg叶黄素组、12 mg叶黄素组或安慰剂组，进行12周的干预试验，并在干预停止后继续观察6周。分别在干预0、1、3、6、9、12和18周采用HPLC法测量血清叶黄素和β-胡萝卜素浓度。采用膳食频率表评价膳食摄入情况。性别之间血清叶黄素浓度未见显著性差异。能量调整后，血清叶黄素浓度与膳食叶黄素、维生素A、维生素C、维生素E、β-胡萝卜素和脂肪的摄入量呈正相关，而与BMI无关。在干预过程中，血清叶黄素浓度在9周达到峰值，在18周返回到基线水平。6 mg叶黄素组和12 mg叶黄素组血清叶黄素浓度分别增长为干预前的1.8倍和2.3倍。干预中未见不良反应及血清β-胡萝卜素的降低。本研究结果显示长期摄取含叶黄素的蔬菜和水果可安全有效地将血清叶黄素浓度维持在较高水平。

關鍵字

叶黄素 ； β-胡萝卜素 ； 类胡萝卜素 ； 相互作用 ； 成年人

並列摘要

Observational epidemiological studies have shown that a high consumption of lutein-containing foods is associated with decreased risk of chronic diseases. However, results are inconsistent, suggesting the possibility that confounders may impact serum lutein concentration after consumption. The present study aimed to determine the factors affecting serum lutein status and to characterize dynamic changes of lutein concentration in serum during lutein supplementation in healthy Chinese subjects. After baseline characteristics were determined, thirty-seven healthy participants were randomized to receive 6 mg lutein/d, 12 mg lutein/d, or placebo for 12 weeks, as well as to be observed for 6 additional weeks after the cessation of supplementation. Serum levels of lutein and β-carotene were measured by HPLC at weeks 0, 1, 3, 6, 9, 12 and 18. Dietary intake was estimated by food-frequency questionnaires. No significant sex differences were found in serum concentration of lutein. Serum lutein level positively correlated with dietary lutein, retinol equivalents, vitamin C, vitamin E, β-carotene and fat intake after adjustment for caloric intake, but not with BMI. After 12-weeks of supplementation, lutein levels increased approximately 1.8-fold and 2.3-fold for the 6-, and 12-mg dose groups respectively, approaching a plateau at week 9, and then decreased to baseline values at week 18. No adverse events or reductions in serum β- carotene were observed throughout the study. Our findings indicate that increasing the consumption of lutein-rich fruit and vegetables can be considered as a long-term, sustainable and safe approach to reach and maintain high serum levels of lutein.

並列關鍵字

lutein ； β-carotene ； carotenoid ； interactions ； adults