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Introduction: Osteosarcoma is the most common primary malignant bone tumor excluding hematopoietic neoplasms. It is thought to arise from a primitive mesenchymal bone-forming cell and is characterized by production of osteoid. Despite osteosarcomas of the jaws being less aggressive than those occurring in the long bones, local recurrence after surgical therapy is a major complication. Case Report: We report a case of recurrent osteosarcoma of maxilla, within three years after surgical resection presenting as a rapidly growing fungating mass in a 24-year-old female. Conclusion: Osteosarcoma affecting the maxilla is a relatively rare condition when compared to the long bones. Early diagnosis and treatment can improve the survival rate. Management of super added fungal infections associated with chemoradiotherapy can prevent further complications and improve the general health of the patient in recurrent lesions.

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