鼻咽癌放射線治療引起之上顎骨肉瘤－病例報告

Radiation-induced Osteosarcoma on Maxilla in Nasopharyngeal Carcinoma-A Case Report

陳佳政(Chia-Cheng Chen) ； 呂邁(Mai Lu) ； 陳韋全(Wei-Chuan Chen)

《臺灣口腔顎面外科學會雜誌》 24卷1期 (2013/03) Pp. 18-27

摘要

鼻咽癌在解剖位置上不易到達，以及較高的遠端轉移機率，臨床上以放射線治療為主，然而放射線治療卻有可能誘發頭頸部周圍的組織產生惡性病變，包括惡性骨肉瘤。惡性骨肉瘤為能製造類骨質的惡性間葉細胞，在原發自骨內的腫瘤中，好發機率僅次於造血組織腫瘤。惡性骨肉瘤發生於顎骨的機率約6%-8%，上下顎發生的機率大致相等。本報告提出一位48歲男性患者，因罹患鼻咽癌接受放射線治療，五年後在定期追蹤時發現罹患上顎骨肉瘤的病例。

關鍵字

鼻咽癌 ； 骨肉瘤 ； 放射線治療引起之骨肉瘤

並列摘要

Nasopharyngeal carcinoma is difficult to cure by surgical resection due to the complicated anatomic position and higher possibility of regional metastasis. Clinically, radiation therapy is the major treatment modality, although it can induce malignancy in surrounding head and neck tissues including osteosarcoma. Osteosarcoma is a malignancy of mesenchymal cells that have the ability to produce osteoid or immature bone. Excluding hematopoietic neoplasms, osteosarcoma is the most common type of malignancy to originate within bone. Osteosarcomas of the jaws areuncommon and represent 6% to 8% of all osteosarcomas. The maxilla and mandible are involved with about equal frequency. Here we report a case of radiation induced sarcoma in a 48 y/o male patient treated for nasopharyngeal carcinoma with radiation who developed osteosarcoma of maxillary bone after five years. The patient was treated with surgery and chemotherapy.

並列關鍵字

Nasopharyngeal carcinoma ； Osteosarcoma ； Radiation-induced sarcoma