膳食脂肪與熱量對於脂質合成之影響

Effect of Dietary Fat and Energy Intake on Lipid Synthesis in Rats

張淑緘(S. C. Chang) ； 郭建楊(J. Y. Guoo) ； 範礪珍(L. J. Fan) ； 陳懋良(M. L. Chen)

《中華民國營養學會雜誌》 4卷2期 (1979/09) Pp. 97-103

https://doi.org/10.6691/JCNS.197909_4(2).0015

摘要

本實驗以白鼠研究膳食中不同脂質含量與熱量限制攝取情況下對動物脂質含成的影響。白鼠在攝取高脂(20%)膳食後，體重增加及肝臟含脂量均增高而體內脂質合成率及肝臟與脂肪組織中蘋菓酸酶及葡萄糖－6－磷酸去氫酶之活性均呈顯著降低。低脂(1%)膳食則促進肝臟脂質合成酶活性及增加脂質合成率。但此種促進效應隨熱量限製而降低。高脂膳食組的白鼠由于體內脂質合成已受抑制，在輕度熱量限製情況下，沒有進一步的影響。因此，影響動物體內脂質合成的主要因素是膳食中脂質含量而限製熱量攝取之影響在膳食脂肪含量較低時較為明顯。

並列摘要

The effect of dietary fat and energy restriction on lipid metabolism was studied in rats. Animals were fed with different fat content diets of isonitrogenous intakes. Energy restriction was achieved by ration-feeding of test diets containing various amount of non-nutritive cellulose in the expense of dietary carbohydrate. When rats were fed with iso-caloric diets, liver malic enzyme (ME) and glucose-6-phosphate dehydrogenase (G6PD) activities were significantly lower in animals receiving high fat (20%) diet, where low fat (1%) stimulate the enzyme activities. In vivo incorporation test showed that higher lipogenesis were obtained in animals receiving low fat diet. When dietary energy was reduced, the stimulative effect of low fat diet on liver enzyme and lipogenesis was markedly diminished. The lowering of llpogenesis was found to be correlated to the degree of restriction. However, restricted energy intake showed to be less effective on liver ME and G6PD which had already been depressed by fat-rich diet (20%). In vivo incorporation also showed similar results. It is apparent that dietary fat content, rather than total caloric intake, could be the primary factor for the change of lipogenesis in animals.

並列關鍵字

Energv intake ； Fat intake ； Lipogenesis ； Liver enzyme