Infuence of Dietary Energy Intake on Protein and Lipid Metabolism in Rats

本研究乃探討限制熱量攝取下，對白鼠之蛋白質及脂質代謝的影響。白鼠飼以定量而含相同氮量的食物，並以20%或40%無熱量的纖維素代替所需的碳小化合物以達限制熱量的目的。攝取的熱量減少時，白鼠的生長、肝中氮含量及氮保留率均呈降低，肝中蘋果酸酶的活性變隨熱量攝取減少而減低，但葡萄糖-6-磷酸去氫酶的活性則無明顯變化。增加食物中蛋白質含量可彌補熱量，可得更明顯的結果。試管中，肝組織以(上標 14)C-笨胺基丙胺酸和(上標 14)C-醋酸含成蛋白質和脂質熱量不足時亦顯較慢，其中對蛋白質合成之影響較脂質更明顯。補充離胺酸可改善白鼠對麩蛋白的利用率，但其效用在熱量攝取不足時顯著減少。上述結果顯示，短期之熱量攝取不足時，主要影響在蛋白質這代謝，而對脂質之合成，影響甚小。

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並列摘要

The effect of dietary energy restriction on protein and lipid metabolism was studied in rats. Animals were fed with isonitrogenous diets and energy restriction was achieved by ration-feeding of test diets containing 20 or 40% of non-nutritive cellulose in the expense of dietary carbohydrate. Rats receiving caloric restricted diet showed lower weight gain, liver nitrogen and nitrogen retention. Liver malic enzyme activity was significantly decreased in energy restricted groups, while glucose-6-phosphate dehydrogenase did not show significant change from that of the unrestricted groups. Increase in the dietary protein level can compensate some of the affect on growth, liver nitrogen and nitrogen retention; but ma lie enzyme activity remained unchanged. And enhanced results were obtained in animals with more severe energy restriction. In vitro incorporation of (superscript 14)C-phenylalanine and (superscript 14)C-acetate into liver protein and lipid also appeared to be slower n energy restricted groups. Of which, protein synthesis appeared to be more conspicuous than lipid. The utilization of gluten by rats was improved by lysine supplementation. However, the beneficial effect of lysine was markedly diminished when energy intake restriction was implemented. Results indicated that the moderate energy -restriction may influence primarily o the protein utilization, whereas lipogenesis was less affected in the present study.

並列關鍵字

Energy intake ； Lipogenesis,Protein ； Utilization

國際替代計量

Infuence of Dietary Energy Intake on Protein and Lipid Metabolism in Rats

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