Hypertension and the Insulin-related Metabolic Syndrome: Factor Analysis in 17,539 Taiwanese

高血壓與胰島素阻抗相關代謝異常症侯群：17539名台灣人之因素分析結果

荘紹源(Shao-Yuan Chuang) ； 陳震寰(Chen-Huan Chen) ； 週碧瑟(Pesus Chou)

《Acta Cardiologica Sinica》 20卷4期 (2004/12) Pp. 229-236

摘要

背景 高血壓是胰島素阻抗相關之代謝異常症侯群的成份之一，然而胰島素阻抗與高血壓之間的關係仍然未有定倫。因素分析法是一種統計方法，可以從一組相關的危險因子變項中，抽取出數個不相關的相素。對相同的因素有貢獻的數個危險因子變項之間，可能具有相同的致病機轉。
方法 隨機抽樣所得之17539位（男性8516位；女性9023位）30歲以上成人健診資料，利用主成分分析法就其心血管疾病危險因子變項進行探索式因素分析。
結果　因素分析分別於男女各區辨出2個獨立因素。男性的第一個因素包括三酸甘油脂、高密度脂蛋白膽固醇、腰圍及身體質量指數（命名為代謝異常症侯群），可以解釋42%的總變異量；第二個因素包括收縮血壓、空腹血糖、腰圍身體質量指數（命名為高血糖加高血壓加肥胖），可以解釋19%的總變異量。女性的第一個因素包括血糖、收縮血壓、腰圍與身體質量指數（命名為高血糖壓加肥胖），可以解釋46%的總變異量；第二個因素包括三酸甘油脂、高密度蛋白膽固醇、腰圍及身體質量指數（命名為代謝異常症侯群），可以解釋17%的總變異量。
結論 台灣地區的成年男女，均呈現明顯之胰島素阻抗相關代謝異常症侯群特質。無論男女，高血壓與代謝異常症侯群的關係均透過肥胖而連結。

關鍵字

因素分析 ； 代謝異常症侯群 ； 胰島素阻抗 ； 高血壓

並列摘要

Background: Hypertension is a component of the insulin resistance-related metabolic syndrome. However, the relationship between insulin resistance and hypertension remains unclear. Factor analysis is a statistical technique that extracts several unrelated components from a set of intercorrelated risk variables. Risk variables contributing to the same component may share the same pathophysiological process.
Methods: Risk variables from 17,539 Taiwanese (8516 men and 9023 women, aged 30 years and older) randomly selected from a large physical checkup database were analyzed using exploratory factor analysis with principal components method.
Results: Factor analysis identified two independent factors for men and women, respectively. In men, a cluster of triglycerides, high-density-lipoprotein cholesterol, waist circumference, and body mass index (metabolic syndrome) accounted for 42%, and a cluster of glucose, systolic blood pressure, waist circumference, and body mass index (hyperglycemia plus hypertension plus obesity) accounted for 19% of the total variance in all variables considered. In women, a cluster of glucose, systolic blood pressure, waist circumference, and body mass index (hyperglycemia plus hypertension plus obesity) accounted for 46%, and a cluster of triglycerides, high-density-lipoprotein cholesterol, waist circumference, and body mass index (metabolic syndrome) accounted for 17% of the total variance.
Conclusion: A distinct insulin-resistance-related metabolic syndrome was observed for both men and women in Taiwan. Hypertension was probably linked to the metabolic syndrome through obesity in both Taiwanese men and women.

並列關鍵字

Factor analysis ； Metabolic syndrome ； Insulin resistance ； Hypertension