- 期刊
- OpenAccess
Targeting Epigenetic Modification in Acute Kidney Injury-Chronic Kidney Disease Continuum
摘要
Acute kidney injury (AKI) and chronic kidney diseases (CKD) are closely interconnected. AKI-CKD continuum has been highlighted recently and accumulating evidence of epigenetic modification during this process has been reported. Epigenetic modification involves DNA methylation, histone modification, and the expression of various non-coding RNAs. For instance, DNA methylation in renal pericytes after AKI promotes CKD. Histone modifications including acetylation, methylation, phosphorylation in renal tubular cells influence renal repair after AKI. Several non-coding RNAs are promising biomarkers of AKI and could predict renal outcomes. Improved understanding of the epigenetic mechanisms of AKI-CKD continuum has shed light on the difficult position of the lack of effective therapies for AKI-CKD continuum. In this review, we summarize the recent research regarding not only the role of epigenetic mechanisms but also novel insights into the new strategies for the diagnosis and therapy of AKI-CKD continuum.
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