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摘要


近年來儘管研究蓬勃發展、醫療水準大幅提升,急性腎損傷仍舊合併相當高的罹病率和死亡率。傳統以血清肌酸酐為依據的診斷標準,存在無法早期診斷的盲點。新興生物標誌的發展,例如嗜中性白血球明膠酶相關性脂質運載蛋白(NGAL)、腎損傷分子1 (KIM-1)、第十八型細胞間素(IL-18)及血清胱蛋白C (cystatin C)等,除了幫助我們更加瞭解急性腎損傷的複雜病生理機轉,也有助於早期診斷、及時介入治療,甚而改善病人的預後。

並列摘要


Over the past decades, despite advanced progress in research and medical, acute kidney injury is still associated with significant morbidity and mortality. Traditional diagnostic criteria of acute kidney injury is based on serum creatinine, which is not a reliable indicator during acute changes of kidney function. Novel biomarkers such as NGAL, KIM-1, IL-18 and cystatin C allow us to unravel the complex pathophysiology of acute kidney injury, and more importantly, to provide the chance of early diagnosis and timely treatment.

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