Objective: Allergic disease is common in Taiwan. It includes allergic rhinitis, asthma, atopic dermatitis etc. The cause of the allergic disease is allergen and common allergens include mite, cockroach, mold, sea food, milk and fruits. In order to understand prevalence of allergens in eastern Taiwan, we tested 1,067 blood sample for allergen specific IgE and the results indicated positive rate at 43.1%. Mite is the most prevalent inhalant allergen and shrimp is the most prevalent food allergen. We hope the study can help clinic diagnosis of allergic diseases.