大台北地區過敏原特異型IgE抗體之陽性比率與嚴重程度

The Positive Rate and Severity Score for Allergen-Specific IgE Antibodies in Taipei Metropolitan Area

周尚芳(Shan-fan Chow)

指導教授 ： 許垤棋

大同大學/工程學院/生物工程學系所/碩士(2011年)

摘要

檢測過敏原特異型IgE抗體已愈發重要，台灣也有論文作者們探討台灣過敏原盛行情形。因此本文以大台北地區過敏原如吸入、食物、植物、黴菌等特異型IgE抗體的陽性比率與嚴重程度，來探討是否與其他地區相似。吾等以RIDA過敏原系統偵測283位病人血清中的特異型IgE抗體。結論：男女在各種過敏原特異型IgE抗體的陽性比率與嚴重程度沒有差異，兒童、青少年、成人的盛行率卻有些不同，屋塵螨與粉塵螨過敏原在不同年齡層之特異型IgE抗體的陽性比率與嚴重程度皆為最高，尤其在青少年階段。多重過敏原致敏化則占90.2%，其中以混合2-5種過敏原最常見，尤其是屋塵蟎加上粉塵蟎和家塵多重致敏化。螨、家塵與食物為最重要的過敏原，此情形與台灣各地區及西方國家類似。

關鍵字

過敏原特異型IgE抗體 ； 陽性比率 ； 嚴重程度 ； 螨 ； 多重致敏

並列摘要

A sensitive assay of allergen-specific IgE antibodies was important to identify the patient’s allergens. Some reports revealed the prevalence of allergens in Taiwan. The aim of this study was to elucidate the positive rate and severity score of inhalant, food, plant and fungal allergens in patients with the allergic syndromes in Taipei metropolitan area. We collected serum samples from 283 patients. The serum samples were measured by RIDA allergy screen system which determined the allergen-specific IgE antibodies. In conclusions, this study had shown that gender made no difference. But the prevalence of allergens was different from the childhood, adolescent, and adult groups. Sensitized to Dermatophagoides pteronyssinus and Dermatophagoides farina in three age stages showed a highly positive rate and severity score, especially in the adolescent stage. There were 90.2% who patients showed polysensitization against over 2 kinds of allergens. Polysensitization appeared to be common with 2-5 kinds of allergens. D. pteronyssinus was frequently associated with polysensitization to D. farinae and house dust. The results indicated that mites, house dust and foods were the major sensitizing allergens in this study were similar to those in Taiwan and other western countries.

並列關鍵字

allergen-specific IgE antibodies ； positive rate ； severity score ； mite ； polysensitization

參考文獻

46.黃璟隆：從台灣地區過敏病的增加談衛生假說。台灣兒童過敏氣喘及免疫學會通訊 2003；4(2) June。

49.Chu SL, Chen KJ, Tsai CY et al: Efficacy of allergen-arrayed chips for detecting allergen-specific immunoglobulin E in allergic patients. Mid Tiwan J Med 2004; 9:96-102.

50.Wu CS, Yu CL, Chang CH et al: Effect and correlation of serum total IgE, eosinophile granule cationic proteins and sensitized allergens in atopic dermatitis patients with or without rhinitis. Kaohsiung J Med Sci 2002; 18:229-35.

65.Chang CF，Ho LH, Xie PY: The Prevalence Rate of Various Allergens in Eastern Taiwan Area by ImmunoCAP. J Biomed Lab Sci 2009; 21(4).. 137-42.

76.Liu YH, Chou HH, Jan RL et al: Comparison of two specific allergen screening tests in different patient groups. Acta Paediatr Tw 2006; 47(3) 116-22+158.