Topical Cylosporine Therapy for Keratoconjunctivitis Sicca in Sjögrens' Syndrome

局部環孢靈素對眼部乾燥症的治療

樊文雄(Wen-Shuang Fan) ； 洪豪良(Hao-Liang Hung) ； 廖旭彬(Hsu-Pin Liao) ； 賴寧生(Nin-Sheng Lai)

《慈濟醫學雜誌》 15卷2期 (2003/04) Pp. 85-89

https://doi.org/10.6440/TZUCMJ.200304.0085

摘要

目的: 本研究旨在探討局部點用環孢靈素治療眼部乾燥症的效用與安全性。病人與方法: 共收集50位病患分為實驗組及對照組，實驗組用0.1%環孢靈素加油性介質，對照組則只用油性介質，兩組眼藥每天使用兩次，期間為三個月。本研究以症狀嚴重度、基礎淚液分泌及眼裂間活體染色作為評估標準。結果:在臨床症狀方面兩組皆有改善，但不具有統計學上明顯的差異。基礎淚液分泌再第三個月及眼裂間活體染色在第一個月及第三個月，兩組皆具有統計上明顯差異。結論:本研究結果顯示，局部環孢靈素可以控制眼部乾燥症的發炎反應及恢復基礎淚液的分泌。(慈濟醫學 2003; 15:85-89)

關鍵字

環孢靈素 ； 眼部乾燥症 ； 淚液分泌

並列摘要

Objective: This study aimed to investigate the thetrapeutic effect and safety of topical Cyclosporine 0.1% in keratoconjunctivitis sicca associated with sjögrens syndrome. Patients and Method: Fifty patients with Sögrens symndrome associated keratocon-junctivits sicca were divided nito two groups. Topical Cyclosporine(CsA) or vehicle control was applied twice a for 3 months. The severity of symptoms, interpalpable Rose Bengal staining scores and Schirmer values were used as outcome evaluations.Results: Subjective symptoms improved in both groups at all intervals; however they did not show any statistical significant differece. The CsA group had a statistically significat improvement in Schirmer value in month 3, and staninig scores in month l and 3 compared with the control group. Conclusion: Topical Cyclosporine treatment may provide control of ocular surface in- flammation and reproduction of baseline tear secretion.(Tzu Chi Med J 2003; 15:85-89)

並列關鍵字

Cyclosporine ； keratoconjunctivitis sicca ； tear secretion