Topical Cyclosporine A 0.05% in the Treatment of Superior Limbic Keratoconjunctivitis

局部環孢靈(cyclosporine A) 0.05%在上輪部角結膜炎的治療

鄭聖甫(Sheng-Fu Cheng) ； 彭繼賢(Chi-Hsien Peng) ； 鄭成國(Cheng-Kuo Cheng)

《中華民國眼科醫學會雜誌》 46卷1期 (2007/03) Pp. 51-55

https://doi.org/10.30048/ACTASOS.200703.0009

摘要

目的：報告一個使用局部環抱靈[cyclosporine A (CSA)]0.05%滴劑成功的治療上輪部角膜結膜炎的案例。
病歷報告：一個21歲的男性，接受局部類固醇以及眼潤滑劑治療上輪部角結膜炎之後，仍持續呈現兩眼結膜充血。他的甲狀腺功能正常，在增加使用局部CSA 0.05%一個月之後，伴隨著異物感和刺激感的改善與結膜水腫和乳突性反應的降低。使用CSA 0.05%治療三個月之後，不適的症狀並沒有復發，也沒有任何併發症發生。
結論：局部的CSA 0.05%在上輪部角結膜炎的輔助治療上是有效而且有益處的。或許需要更進一步的研究來評估其初次治療的角色以及預防復發的效果。

並列摘要

Purpose: To report a case with superior limbic keratoconjunctivitis (SLKC) treated with topical cyclosporine A (CSA) 0.05% drops successfully.
Case report: A 21-year-old male with SLKC treated with topical corticosteroids and lubricants showed persistent conjunctival congestion in both eyes. His thyroid function was normal. Added topical CSA 0.05% drops were used with improvement of irritation and foreign body sensation, as well as decrease of conjunctival edema and papillary reaction one month later. He remained asymptomatic on topical CSA 0.05% for 3 months without complications.
Conclusions: Topical CSA 0.05% is effective and beneficial as adjunctive therapy for SLKC. Further study may be needed to delineate the role of primary use and maintenance to prevent recurrence.

並列關鍵字

Superior limbic keratoconjunctivitis ； cyclosporine A