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  • 期刊

Coinfection with Leptospirosis and Scrub Typhus-A Report of Four Cases

鉤端螺旋體感染合併恙蟲病-四個臨床病例報告

摘要


鉤端螺旋體感染與恙蟲病為人畜共通傳染病,鉤端螺旋體感染是經由破損的皮膚或黏膜感染,恙蟲病是經由遭受Orientia tsutsugamushi感染的恙蟲叮咬而致病。二者臨床表現類似,臨床表現不易區分。我們收集四位個案合併鉤端螺旋體及恙蟲病感染,一位病患死亡,其餘三位存活,診斷方法包括血清抗體IgG四倍上升或多聚合酵素鏈鎖反應(PCR)陽性。鉤端螺旋體合併恙蟲病感染臨床表現不易區分,早期二者均可造成發燒、頭痛、皮疹、肌肉疫痛、結膜充血。兩者對於嚴重病患均可造成多重器官衰竭包括肺炎、腦炎、心肌炎、急性腎臟衰竭、肝炎及泛發性血管內血液凝固症。醫師對於發燒病患如有野外或動物接觸病史等應提高警覺是否有合併感染之可能,早期用藥可提高病患存活率,aqueous penicillin合併新一代的fluoroquinolone為本院目前針對疑似非典型感染之病患的處理原則。

並列摘要


Leptospirosis and scrub typhus are zoonoses with worldwide distribution. The spectra of clinical severity are wide for both diseases, ranging from mild to fatal. A diagnosis of coinfection with leptospirosis and scrub typhus can be difficult to make if the exposure history is overlooked but patients can die if not treated early. Herein we present four such cases, one patient died due to delayed diagnosis, while the other three survived without sequelae.

並列關鍵字

leptospirosis scrub typhus coinfection

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