芍藥藥材加工方法與基準方劑中芍藥苷含量變化之探討

Studies of Paeoniflorin Contents in Paeonia Lactifloria from Different Preparations and Prescriptions in Taiwan

李威著(Vei-Juh Lee) ； 張永勳(Yuan-Shiun Chang) ； 劉晉魁(Chin-Kuei Liu) ； 何禮剛(Li-Kang Ho) ； 謝明村(Ming-Tsuen Hsieh)

《中醫藥雜誌》 9卷3期 (1998/09) Pp. 145-155

https://doi.org/10.6940/JCM.199809_9(3).04

摘要

本研究以高效液相層析(HPLC)對不同來源芍藥藥材中paeoniflorin與以定量分析，比較其不同加工方式對成分的影響，以及探討中藥毒基準方中合芍藥基準方劑中paeoniflorin的移行率，以作爲藥材良窳選擇與實施中學基準方後中禁製劑的參考，以助中藥的現代化與科學化。結果發現，蠲痹湯之標準湯劑及浸膏劑之移行率爲單味劑材之83.86%及73.69%；血府逐瘀湯爲67.69%及66.36%；小青龍湯爲91.56%及88.39%；四物湯爲91.17%及91.49%；百合固金湯爲95.40% 及90.72%桂枝湯爲80.22%及83.60%；八珍湯爲90.84%及82.50%；獨活寄生湯爲81.56%及82.44%；完帶湯爲86.42%及77.56%。至於不同加工方式之芍藥藥材所含paeomflorin之含量實驗部分，確定了杭芍與毫芍於原產地之加工方式不同，杭芍爲先削皮後煎煮，毫芍爲先煎煮後削皮。

關鍵字

芍藥 ； 芍藥苷 ； 移行率

並列摘要

In order to proceed a stable quality for Chinese preparations, the government promulgated GMP projects in conduction of the manufactory of Concentrated Extract Chinese herbal Medicine. The Department of Health also standardized the Chinese Herbal Preparations for the control of quality. It is important to preserve the bioactive constituents while processing concentration of Chinese Herbal Medicine. In the present study, the turnover rates of paeoniflorin from different preparations and prescriptions were evaluated by HPLC quantities. The turnover rates of paeoniflorin were defined as the percentage yields of this component in different Chinese Medical Prescriptions. The results indicated that the turnover rates of Combination and Extracts in Juan-Bi Tang were 83.86% and 73.69%, respectively. The rates was 67.69% and 66.36% in Xue-Fu-Zu-Yu Tang; 9 1.56% and 88.39% in Xiao-Qing-Long Tang; 91.17% and 9 1.49% in Shy-Wuh Tang; 95.40% and 90.72% in Bai-He-Gu-Jin Tang; 80.22% and 83 .60% in Gui-Zhi Tang; 90.84% and 82.50% in Ba-Then Tang; 8 1.56% and 82.44% in Du-Huo-JiSheng Tang; 86.42% and 77 .56% in Wan-Dai Tang. Besides, Hanh-Shao and Buo-Shao were prepared differently in the origin sites. Hanh-Shao was pealed before further agitating. Buo-Shao was agitated before peeling.

並列關鍵字

Paeonia lactifloria ； Paeoniflorin ； Turnover rate