局部晚期口腔癌之治療

Treatment of Locally-Advanced Oral Cavity Cancer

孫立民(Li-Min Sun) ； 梁雲(Wan Leung) ； 王重榮(Chong-Jong Wang) ； 陳惠君(Heuy-Jiun Chen) ； 秦有育(Yow-Yue Chin) ； 吳嘉明(Jia-Ming Wu)

《中華放射線醫學雜誌》 19卷2期 (1994/06) Pp. 137-142

摘要

A series of 118 cases with locally-advanced (AJCC stage T3 or T4) oral cavity squamous cell carcinoma receiving radical surgery and/or radiotherapy between July 1986 to April 1992 were retrospectively analyzed.
The primary sites included buccal mucosa, oral tongue, hard palate, lip, gingiva, and mouth floor. According to the treatment methods, we classified the patients in three groups. The first group of patients were treated by radical surgery alone (S, 49 cases), the second group of patients were treated by radiotherapy alone (RT, 26 cases), and the third group of patients were treated by surgery and post-operative radiotherapy (S+RT, 43 cases). The 2-year actuarial survival rates were 38.8%, 26.9 %, and 44.3%, respectively. There was significant difference between S and RT or between S+RT and RT, but it might be due to the case selection effect of surgery. Local regional recurrence rates were 38.7%, 28.6%, 26.7% (P＞0.05) for S, RT, and S+RT, respectively. In the S+RT group, there was no obvious relationship between survival and total dose (＜6000cGy vs. 6000cGy).
More patients in the combined modality therapy group suffered from treatment related complications. In this group, they received radical surgery and higher dose of post-operative radiotherapy, and their life quality was relatively poor.

關鍵字

頭頸部腫瘤 ； 頭頸部腫瘤放射治療學 ； 術後放射治療

並列摘要

A series of 118 cases with locally-advanced (AJCC stage T3 or T4) oral cavity squamous cell carcinoma receiving radical surgery and/or radiotherapy between July 1986 to April 1992 were retrospectively analyzed.
The primary sites included buccal mucosa, oral tongue, hard palate, lip, gingiva, and mouth floor. According to the treatment methods, we classified the patients in three groups. The first group of patients were treated by radical surgery alone (S, 49 cases), the second group of patients were treated by radiotherapy alone (RT, 26 cases), and the third group of patients were treated by surgery and post-operative radiotherapy (S+RT, 43 cases). The 2-year actuarial survival rates were 38.8%, 26.9 %, and 44.3%, respectively. There was significant difference between S and RT or between S+RT and RT, but it might be due to the case selection effect of surgery. Local regional recurrence rates were 38.7%, 28.6%, 26.7% (P＞0.05) for S, RT, and S+RT, respectively. In the S+RT group, there was no obvious relationship between survival and total dose (＜6000cGy vs. 6000cGy).
More patients in the combined modality therapy group suffered from treatment related complications. In this group, they received radical surgery and higher dose of post-operative radiotherapy, and their life quality was relatively poor.

並列關鍵字

Head and neck neoplasms ； head and neck neoplasms, therapeutic radiology ； therapeutic radiology, postoperative