生技碟片檢測系統之開發研製

Prototyping of a Biomedical Compact Disc Inspection System

李福星(Fu-Shin Lee) ； 黃忠仁(Jong-Zen Huang) ； 鄭文源(Wen-Yuan Zheng) ； 曾劭鈞(Shao-Chin Tseng)

《科儀新知》 154期 (2006/10) Pp. 73-85

https://doi.org/10.29662/IT.200610.0009

摘要

本文探討近年在生醫檢測趨勢中漸受相關業界重視之生技碟片的檢測系統，其基本設計技術主要為結合壓電微動變焦之生醫光學檢測平台、半導體或機械精密加工製程之微流道設計、檢體螢光反應之影像檢測技術，以及應用高度開發之光碟機控制技術並儲存媒體資訊擷取機制等。筆者先簡介生技碟片檢測系統之基本原理與平台架構設計，再分別探討本研究團隊開發實瞼階段中，生技碟片之桌上型與嵌入型共軛焦(con-focal)兩種檢測架構設計流程。主要為其應用共軛焦與變焦原理並採取壓電體致動之鏡頭系統，可進行影像縮放及檢體光學切片之生醫檢測功能，而其後檢體受激放射螢光可透過通訊監控系統之影像處理機制，藉由進行檢體反應特徵辨識工作，達到即時檢測目地。

並列摘要

The object of this paper is to discuss the basic design approach for a bio optical compact disc (BioCD) system, which has drawn extensive attentions within the biomedical industries during last decade. The related researches are becoming more valued due to a BioCD typical system usually integrates an optical focusing platform operated by piezoelectric actuators, well-managed micro- channels on the discs fabricated by semiconductor or micro-stamping manufacturing, an image processing mechanism for the collected fluorescence from the specimen reactions, and the highly developed optical disc driving mechanisms as well as the optic media coding technologies. In this paper, the basic principles of con-focal mechanisms and structure design of a BioCD system are stated first, and then followed with the inductions of a desktop as well as an embedded BioCD approaches. Essentially, both of introduced systems employ con-focal principles and piezoelectric actuators to design a three-group lens system, which is aimed to achieve fluorescence image amplification as well as optical slicing functions for the specimen. In the last, the collected slicing images of the specimen could be transmitted to an image processing mainframe, which is used to conduct certain pattern recognition and symptom identifications.