常壓電漿系統於快速質譜分析術之應用

Atmospheric Pressure Plasma for Rapid Mass Spectrometry Detection

江政鴻(Cheng-Horn Chiang) ； 陳俊邑(Chun-Yi Chen) ； 林哲信(Che-Hsin Lin)

《科儀新知》 227期 (2021/06) Pp. 60-72

摘要

近年來質譜分析的發展十分迅速，其快速半定量檢測的特性，對於瞭解樣本中特殊化學成分具有優勢。然質譜分析法需使用一游離源使樣品游離後帶電，此一過程往往需要複雜的樣本前處理的程序。因此傳統質譜分析法在面對需要大量及快速偵測的應用時，就會遇到瓶頸。而常壓電漿質譜游離法可以直接在常壓中進行樣本游離，且過程完全不需要抽真空或是進行隔離，所以可以快速且連續地分析樣本，而且可不需進行複雜的樣本前處理程序，因此大幅提升了質譜量測的效能。然而，常壓電漿質譜法因電漿僅對於小分子量之弱極性物質具有較好的游離效果，對於水溶性的大分子極性物質感度較差。因此，本文提出一種創新之同軸雙游離源系統，其整合了電漿產生器以及電噴灑游離裝置，可使兩種具有電位之離子源可以穩定共存，並同時對極性以及非極性物質進行質譜偵測。

並列摘要

Mass spectrometry is a rapid growth technique for semi-quantification detection of various molecules without using the delicate sample preparation processes. In general, it is essential to charge the sample molecules prior to mass analyzing with the mass spectrometer. Therefore, the atmospheric pressure plasma source is an ideal ion source to charge the sample molecules for mass spectrometry detection since no vacuum chamber is required to produce the charged ions. However, this method is usually good for detecting the molecules with low-polarity or non-polarity. The detection performance for analyzing polar molecules which dissolved in the liquid samples is limited. This research develops an innovative co-axial ion source composed of dual ion sources including an atmospheric pressure plasma and an electrospray ion sources for for rapid MS detection of pesticides. With this approach, polar and non-polar molecules can be simultaneously detected with the mass spectrometer.