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慢性鼻及鼻竇炎的病理機轉及診斷

Pathogenesis and Diagnosis of Chronic Rhinosinusitis

摘要


慢性鼻及鼻竇炎(CRS)是鼻腔和鼻竇腔發炎性疾病,可併有息肉(CRSwNP)或無息肉(CRSsNP)生成。CRS嚴重影響患者的生活品質,降低工作效率,並消耗鉅量的醫療費用。儘管已有許多的研究了解其病理機轉,但其機轉屬多重因素故仍然知之甚少。EPOS2020數百頁的內容網羅了晚近的各項研究證據,更新了CRS的各項知識,本文將據以介紹CRS的誘發因素、病理機轉、診斷及鑑別診斷,著重於最近的研究證據,為我們當前關於CRS炎症過程的知識提供新的啟示,進一步揭開其發病機理的面紗。

並列摘要


Chronic rhinosinusitis (CRS) is an inflammatory disease of the sinonasal cavity. It can be classified as CRS with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). CRS seriously affects the quality of life of patients, reduces work efficiency, and results in high medical expenses. Although many recent studies have helped in understanding the pathogenesis, it is still not well clarified due to its multifactorial nature. The EPOS2020 reports much recent research evidence and updates knowledge on CRS. This article will introduce the predisposing factors, pathogenesis, and diagnosis/differential diagnosis of CRS. Focusing on recent research evidence can further unveil current knowledge about the inflammatory process of CRS, and its pathogenesis.

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