- 期刊
兒茶素對於基因在動脈粥樣硬化的潛在效果
Effect of Green Tea Polyphenols on the Genes with Atherosclerotic Potential
摘要
動脈粥樣硬化（atherosclerosis）之基因組為源自介於基因譯碼LDL－受體（LDL－R）, LXR－α、PPARs（α、γ）、CD36與C-myc之間的片斷對話結果。因為這些基因控制著在動脈血管壁內之脂質代謝（lipid metabolism）活性、胞激素生成與細胞作用。而綠茶多酚亦即兒茶素對這個基因體之影響，顯示出兒茶素會將基因譯碼之PPAR－γ、CD36、LXR－α、C－myc向下調整；同時關聯在轉錄作用層級，將LDL－R與PPAR－α之基因譯碼向上調整的能力。以這種為根據的結果，有人提出兒茶素有足夠能力來抑制動脈粥樣硬化病灶之發生。
關鍵字
無資料並列摘要
The genomics of atherosclerosis can arise as a result of cross-talk between the genes coding for the LDLreceptor (LDL-R), LXR-＜, PPARs (＜,©), CD36 and C-myc because these genes control lipid metabolism, cytokine production and cellular activity within the arterial wall. The effect of green tea polyphenols (GTPs) upon such genomics revealed their ability to down-regulate genes coding for PPAR-©, CD36,LXR-＜, C-myc coupled with up-regulation of genes coding for LDL-R and PPAR-＜at the transcriptional level. Based upon these results, it is proposed that GTPs have the inherent capacity to inhibit the development of atherosclerotic lesions. Copyright c 2004 John Wiley & Sons, Ltd.
延伸閱讀
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