Propine眼藥水於青光眼治療之評估

Clinical Evaluation of Propine (Dipivefrin HC1) on Glaucoma Treatment

瞿錦春(Jiin-Chuen Chiu) ； 周清光(Ching-Kuang Chou)

《中華民國眼科醫學會會刊》 29卷1期 (1990/05) Pp. 253-257

https://doi.org/10.30048/ACTASOS.199005.0045

摘要

0.1% Propine(Dipivefrin，DPE)點入9位正常人及10位原發性隅角開放性青光眼(POAG)之病人眼後，於1、2、4、6、12小時分別記錄眼壓、瞳孔大小、血壓、脈搏等變化，並相互比較。
控制組及實驗組就眼壓降低幅度而言，平均前者為2.1±1.7mmHg，後者為5.9±1.2mmHg；達到眼壓最低之時間平均為4.5小時。瞳孔放大於點藥後兩小時最明顯，平均放大幅度兩組約接近1mm。對兩組人的血壓及脈搏而言，均無明顯變化。僅實驗組一人(10%)在點藥後有些微剌痛感。
另外，對9位POAG患者（15眼）一天點藥兩次，觀察4至6週，有4人（6眼）眼壓控制不穩，其餘眼壓均在20mmHg以內。

並列摘要

Single close study of 0.1% DPE on 10 normal eyes and on 10 open-angle glaucoma eyes was conducted. The mean intraocular pressure reduction was 2.l±l.7mmHg in control eyes and 5.9±1.2mmHg in glaucoma eyes. Pupil dilatation was around 1mm in both groups. There were no significant changes in blood pressure and pulse rate in both groups. In study group, one patient had sting sensation. We also evaluated the midterm effects of 0.1% DPE in 9 (15 eyes) open-angle glaucoma patients. Out of 6 eyes of 4 patients needed to add more medication during follow up. The others (9 eyes) could maintain within normal limit.

並列關鍵字

Propine ； Dipivefrin ； Ocular Hypotension Effect ； Primary Open Angle Glaucoma