0.1% Lodoxamide Tromethamine對眼睛過敏性疾病的臨床效果評估

Clinical Efficacy of Lodoxamide Tromethamine 0.1% on Ocular Allergic Disorders

陳尚群(Chang-Chun Chen) ； 尤之浩(Jy-Haw Yu) ； 何一滔(Ye-Tau Ho)

《中華民國眼科醫學會雜誌》 33卷4期 (1994/12) Pp. 439-443

https://doi.org/10.30048/ACTASOS.199412.0001

摘要

Lodoxamide Tromethamine為一新合成的藥品，具有抑制肥大細胞去顆粒作用及嗜伊紅白血球趨化作用之雙重效能。本文將此成份的眼藥水單獨使用於三十位患春季角結膜炎、過敏性結膜炎與戴隱型眼鏡有關巨大乳突結膜炎等過敏性眼疾，在連續施用二個月過程中，觀察其臨床變化。結果發現在主觀與客觀的眼睛症状、徵候方面有明顯的改善。
本篇另外收集三十位過敏性眼疾患者，隨機一眼點Lodoxamide Tromethamine 0.1%，另一眼則點Sodium Cromoglycate 2%，比較其差異。在連續一個月的觀察中發現，前者具較迅速的作用時間與較輕微的刺激感等優點。經過一個月完整的治療，兩者在症状與徵候的改善方面，並無明顯差異。

並列摘要

Lodoxamide tromethamine is a topical medication which inhibits both mast cell degranulation and eosinophil chemotaxis. This dural mechanism is relatively new to eyedrops and is advantageous to treatment of ocular allergic disorders. Thirty patients including vernal conjunctivitis, allergic conjunctivitis, and soft contact lens related giant papillary conjunctivitis were treated with lodoxamide eyedrops four times a day for two months without using additional steroids throughout the course. Lodoxamide demonstrated significantly subjective and objective improvement on several follow-up visits in the ocular symptoms and signs. Also thirty ocular allergic patients were treated with lodoxamide in one eye and 2% sodium cromoglycate in another eye. In this comparative study versus 2% sodium cromoglycate, lodoxamide demonstrated slightly better on the fast onset of action and milder intensity on the stinging sensation upon drug instillation. After one month treatment period, lodoxamide and 2% sodium cromoglycate showed no obvious statistical difference on the improvement of ocular symtoms and signs.

並列關鍵字

Lodoxamide Tromethamine ； Vernal keratoconjunctivitis ； Eosinophil chemotaxis