Recoverin-Associated Retinopathy: A Case Report and Literature Review

Recoverin抗體相關之視網膜病變：病例報告及文獻回顧

洪如頤(Ju-Yi Hung) ； 方怡謨(I-Mo Fang)

《中華民國眼科醫學會雜誌》 53卷1期 (2014/04) Pp. 48-54

https://doi.org/10.30048/ACTASOS.201404_53(1).0008

摘要

目的：報告一例Recoverin抗體相關之視網膜病變及文獻回顧。方法：病例報告。結果：這位79歲女性來門診時抱怨突發性左眼視力模糊，矯正後最佳視力左眼2/200，右眼20/20。眼底檢查僅發現視網膜小動脈略狹窄，視神經盤輕微蒼白。視野檢查顯示兩眼中央三十度內週邊嚴重缺損，視力較差之左眼出現中央視野喪失。光學同調斷層掃描儀發現左眼黃斑部厚度較薄，視網膜電圖訊號明顯衰退。西方墨點免疫染色血液檢查發現Recoverin抗體。目前未發現癌症病兆，所以診斷病人為Recoverin抗體相關之視網膜病變。結論：根據文獻，癌症相關之視網膜病變被證實和Recoverin等抗體有關，許多案例在過去三十年已被提出並廣泛被接受。此病人臨床表現類似癌症相關之視網膜病變，也發現Recoverin抗體，但追蹤一年半來未診斷任何癌症病兆，過去文獻也曾發表過類似案例，但相對數量較少，因此提出此案例並做文獻回顧。

並列摘要

Purpose: To report a case of recoverin-associated retinopathy. Method: A case report. Result: A 79-year-old woman complained of sudden blurred vision in her left eye. The corrected visual acuity was 20/20 in the right eye and 2/200 in the left eye. A fundus exam showed attenuation of the arterial vasculature and mild optic disc pallor. Optical coherence tomography revealed thinner macula thickness than that of the fellow eye. The electroretinogram demonstrated a marked decrease. Antibody testing involving Western immunoblots identified recoverin antibodies (23kDa). Serum biomarkers of autoimmune disease were negative. After a series of malignancy surveys, no hematological or solid tumor was found. Therefore, recoverin-associated retinopathy syndrome was impressed and discussed. Conclusion: Cancer-associated retinopathy (CAR) has been documented for the past 30 years and recoverin is the most commonly implicated autoantibody. However, recoverin-associated retinopathy is relatively rare. We offer this case, diagnosed as recoverin-associated retinopathy without malignancy, and an associated literature review.

並列關鍵字

Recoverin-associated retinopathy ； Autoimmune retinopathy ； Cancer associated retinopathy-like syndrome