Lung Cancer with Skin Metastasis: Report of 12 Cases

肺癌合併皮膚轉移：12病例報告

柯皓文(How-Wen Ko) ； 林裕清(Yu-Ching Lin) ； 黃秀芬(Shiu-Feng Huang) ； 蔡熒煌(Ying-Huang Tsai) ； 陳志弘(Chih-Hung Chen)

《胸腔醫學》 19卷5期 (2004/10) Pp. 346-351

https://doi.org/10.29806/TM.200410.0005

摘要

肺癌合併皮膚轉移並不常見，但皮膚病灶的確認則很重要，因為它有可能是肺癌的第一個表徵。我們回顧研究從2000至2003年間，12位曾在本院接受治療及追蹤的肺癌合併皮膚轉移的病人之病歷資料。其中有6位病人病理切片證實為肺腺癌，有4位為肺鱗狀上皮癌，小細胞肺癌則有2位。最常發生皮膚轉移的部位為前胸壁及腹壁。皮膚病灶的表現可以是單一結節，多發性結節，或斑塊。有一病人則是以少見的蜂窩性組織炎合併膿瘍來表現。12位病人中有11位病人在接受皮膚切片或細針抽吸時，已有遠端轉移。自皮膚轉移確定診斷後，平均存活期為2.9個月（95%信賴區間，0到5.8個月）。有3位病人在出現皮膚轉移後，存活時間超過一年。我們的結論是，肺腺癌是肺癌合併皮膚轉移最常見的細胞型態。其預後很差，因為它通常是生命終末的表徵。

關鍵字

肺癌 ； 皮膚轉移

並列摘要

Metastasis to the skin from lung cancer is less common than metastasis to other organs. Identifying the skin lesion is important because it can be an initial manifestation of the underlying malignancy. We clinically reviewed 12 cases of lung cancer with skin metastasis, from Jan 2000 to Dec 2003. The pathologic findings included adenocarcinoma in 6 patients, squamous cell carcinoma in 4, and small cell carcinoma in 2. The most common sites of skin lesions were the anterior chest wall and abdominal wall. The lesions could present as a solitary mass, multiple nodules, or a plaque. One patient developed skin metastasis in the form of cellulitis. Of the 12 patients, 11 exhibited other metastatic diseases, which were diagnosed radiologically or pathologically at the time of skin biopsy. Median survival from the diagnosis of skin metastasis was 2.9 months (95% CI, 0 to 5.8 months). Three patients lived more than 1 year after the appearance of skin metastasis. In conclusion, adenocarcinoma is the predominant cell type of skin metastasis from lung cancer. The prognosis is poor, because it always represents a terminal manifestation.

並列關鍵字

lung cancer ； skin metastasis