Upper airway obstructions can be divided by cause into acute and non-acute cases. The diagnosis requires a high degree of clinical suspicion. Tumors generally present as a non-acute cause of upper airway obstruction. We report a rare case with a supraglottic nodule who presented with acute respiratory failure. This 60-year-old woman was brought to our hospital with acute hypercapnic respiratory failure complicated by a disturbance of consciousness; her past history was notable for growth retardation, hypertension, and asthma. After dual ectopic thyroid glands had been diagnosed at the tongue root and larynx, surgical excision of the supraglottic tumor was performed and the patient made a full recovery.