- 期刊
Pitfall in Diagnosing Lymphoepithelioma-like Carcinoma of the Lung: A Case Report and Literature Review
診斷肺原發類淋巴上皮細胞癌上的陷阱－病例報告與文獻回顧
摘要
肺原發類淋巴上皮細胞癌是一少見的肺癌。診斷需要組織切片來做免疫組織化學染色。其預後比其他的非小細胞肺癌好。我們報導一個60歲男性表現出肺中心部腫瘤併肋膜腔積液。氣管內視鏡超音波經氣管細針抽吸得到的少量細胞，形態學上像鱗狀上皮細胞癌。但經胸腔鏡切片發現高惡性度細胞排列成實質片狀，有不等的淋巴球浸潤且雜交檢測EB病毒編碼的RNA發現EB病毒基因在癌細胞核中。診斷為肺原發類淋巴上皮細胞癌且病人接受鉑金類為主的化學藥物治療。
並列摘要
Lymphoepithelioma-like carcinoma (LELC) of the lung is a rare form of lung cancer. The diagnosis requires tissue biopsy for histological and immunohistochemical stain. The prognosis is better than for other non-small cell lung cancers (NSCLC). We report a 60 year-old man who presented with a central pulmonary mass and pleural effusion. Scanty tissue from endobronchial ultrasonography with transbronchial needle aspiration (EBUS-TBNA) resembled squamous cell carcinoma morphologically. But biopsy via thoracoscopy showed high grade tumor cells arranged in a solid sheet pattern, infiltrated by varying numbers of lymphocytes. In situ hybridization for Epstein-Barr virus (EBV) encoded RNA showed localization of EBV genomes within the nuclei of tumor cells. LELC of the lung was diagnosed, and the patient received platinum-based chemotherapy.
延伸閱讀
- Chan, P. C., Chang, C. C., & Lin, C. H. (2013). 原發性支氣管內許旺細胞瘤併存同側肺腺癌：病例報告與文獻回顧. 胸腔醫學, 28(1), 44-50. https://www.airitilibrary.com/Article/Detail?DocID=10239855-201302-201302220027-201302220027-44-50
- Cheng, J. S., Wu, C. L., & Chang, H. Y. (2014). 免疫健全病人之瀰漫性禽結核分枝桿菌感染以肺部轉移癌表現－病例報告及文獻回顧. 胸腔醫學, 29(3), 182-188. https://www.airitilibrary.com/Article/Detail?DocID=10239855-201406-201405160018-201405160018-182-188
- Tsai, Y. M., Huang, M. S., Tsai, J. R., Su, Y. C., Liu, Y. C., & Hwang, J. J. (2008). 原發性肺惡性淋巴瘤－淋巴漿細胞惡性淋巴瘤：病例報告及文獻回顧. 胸腔醫學, 23(2), 95-102. https://doi.org/10.29806/TM.200804.0004
- Chen, C. Y., Chang, Y. L., Chen, K. Y., Lee, Y. C., & Yang, P. C. (2007). 黏液型細支氣管肺泡癌－病例報告與免疫組織化學染色的評估及預後之文獻回顧. 胸腔醫學, 22(2), 98-105. https://doi.org/10.29806/TM.200704.0004
- Liu, W. L., Ku, S. C., & Yang, P. C. (2006). 肺部轉移性惡性黑色素細胞瘤合併支氣管內侵犯－一病例報告與文獻回顧. 胸腔醫學, 21(2), 182-189. https://doi.org/10.29806/TM.200604.0007