- 期刊
Docetaxel-Induced Pneumonitis Following Chemotherapy for Non-Small-Cell Lung Cancer: A Case Report and Literature Review
非小細胞肺癌化學治療後併發Docetaxel引起之過敏性肺炎：病例報告以及文獻回顧
摘要
Docetaxel 引起之過敏性肺炎是一較罕見的副作用，目前只有少數的文獻報告。但此副作用所造成的致死率是不可輕忽的。我們報告一個67 歲男性的病例：他是一位第二期非小細胞肺癌的病患，一開始接受肺葉切除手術和術後的輔助性化學治療。在後續追蹤的過程中發現有肝臟轉移。所以又接受了肝葉切除手術和docetaxel 的化學治療。做了兩次化療後，因感到呼吸困難來門診就醫，經一系列檢查後，被診斷為docetaxel 引起之過敏性肺炎。因此立刻停止docetaxel 的使用，並投予prednisolone 治療，病患的症狀在治療後有明顯地改善。此案例報告提醒內科醫師需注意docetaxel 可能引起的過敏性肺炎，能做到早期診斷和早期治療，期望能得到較佳的預後。
並列摘要
Docetaxel-induced pneumonitis is a rare side effect, with only a few brief case reports in the literature, but the mortality rate can be high. We herein present the case of 67-yearold male diagnosed with stage IIA squamous cell lung cancer in the right lower lobe. He underwent right lower lobe lobectomy and lymph node dissection with adjuvant chemotherapy. However, he was found to have lung cancer recurrence with liver metastases during followup. He then received laparoscopic hepatectomy and chemotherapy with weekly docetaxel. After 2 courses of chemotherapy, he became extremely dyspneic. Docetaxel-induced pneumonitis was highly suspected, so the docetaxel was withdrawn and oral prednisolone was prescribed. His dyspnea improved significantly after treatment. This case report can serve as a reminder to physicians of the adverse effects of docetaxel, so that in the event of their occurrence, counteracting treatment can be initiated as soon as possible.
延伸閱讀
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