- 期刊
IgG4-Related Lung Disease in a Patient with Systemic Lupus Erythematosus: A Case Report
IgG4 相關肺部疾病合併紅斑性狼瘡：病例報告
摘要
IgG4-related lung disease (IgG4-RLD) is an uncommon clinicopathological entity. It is a pulmonary manifestation of IgG4-related disease. Lymphadenopathy of IgG4-RLD makes it difficult to distinguish from lung cancer. We report a 67-year-old male patient with IgG4- RLD and systemic lupus erythematosus. His initial presentations in the health examination were an elevated serum creatinine level, anemia, leukopenia and lung tumor. Abdominal magnetic resonance imaging showed marked swelling at the pancreatic head and multiple wedge-shaped lesions in both kidneys. The video-assisted thoracic surgery wedge resection lung specimen had features that met all histologic diagnostic criteria for IgG4-RLD. Under corticosteroid and azathioprine treatment, the serum IgG4 level, renal function and pancreatic lesion improved gradually. When IgG4-RLD is suspected clinically, the serum IgG4 level measurement and surgical lung biopsy are important diagnostic tools.
並列摘要
IgG4相關肺部疾病是IgG4相關疾病的肺部表現，為一相當罕見的疾病，因常合併淋巴結病變，影像上不易與肺癌區分。本篇文章探討一位六十七歲、IgG4相關肺部疾病合併紅斑性狼瘡的病人，一開始在健康檢查中發現肌酸酐上升、貧血、白血球低下與肺部腫塊，腹部磁振造影可見胰臟腫大及雙側腎臟病灶，經胸腔內視鏡影像輔助手術肺部切片證實為IgG4相關肺部疾病，胰臟腫大在治療後漸漸改善，血清IgG4濃度亦逐漸下降。當發現有肺腫瘤，懷疑為IgG4相關肺部疾病，血清IgG4濃度及胸腔內視鏡影像輔助手術肺部切片為疾病診斷的重要工具。
延伸閱讀
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