摘要
現今以捕捉中子的方法間接把中子的劑量傳遞給病灶的媒介首推硼捉中子的方法研究的最多，但硼捉中子的方法尚有些困難存在，例如氦離子和鋰離子的行走路徑太短，無法有效打斷細胞核內的染色體，硼化合物在人體中之腫瘤下沉組織濃度比，腫瘤血液濃度比有時并無法達到理想的狀態，于是本篇文獻比較不同的媒介而探討中子法的公優缺點，以便達到相輔相成的目的，使的中子捕捉治療法有更多的選擇機會。本篇選用的中子捕捉治療法之媒介是-157。實驗結果證實：腫瘤部位有250ppm濃度之釓，加上給予5x10exp 12n/cm2之熱中了通量，便能給予直徑2公分或更大範圍災害腫瘤20Gy之劑量。
關鍵字
無資料並列摘要
Recently efforts in clinical trial of treating brain tumors with boron neutron capture therapy are very encouraging. Researchers around the world are once again making efforts to deveolp this therapeutic modality. Gadolinium-157 is one of the nuclides that holds interestion properties of being a neutron capture therapy agent. It is estimated that tumor concentrations of up to 300 micro g Gd-157/g tumor can be achieved in brain tumors with some MRI contrast agents such as Gd-DTPA and Gd-DOTA, and up to 800 micro g Gd-157/g tumor can be establisfed in bone tumor, neutron capture therapy can deliver 2000cGy to a tumor of 2-cm diameter or larger with 5x10 exp 12 n/cm2 of thermal neutron fluence at the tumor. Dose measurements with films and TLDs in phantoms verified these calculations. More extended Monte Carlo calculations demonstrate that neutron capture therapy with Gd possess comparable dose distribution to Boron beutron capture therapy.
並列關鍵字
無資料延伸閱讀
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