- 期刊
職業鉛與噪音暴露對於聽覺能力影響－橫斷式研究
Lead Exposure and Effects on Hearing in a Battery Manufacturing Plant-Cross-Sectional Study
摘要
Few epidemiologic studies have been carried out of heavy metals, which have been suggested to be ototoxins in humans, in the environment. Based on these epidemiologic studies, heavy metals such as lead, arsenic and manganese may cause hearing loss in humans and animals. No other metal presents a broader range of problems, from the multiplicity of potential routes of exposure to the spectrum of affected organs and systems, than lead. This cross-sectional study was conducted to examine the relationship among blood lead, noise exposure and auditory ability at a lead battery manufacturing factory. The workers were divided into a lead combined noise-exposed group of 75 workers, and a reference group of 51 persons who were not occupationally exposed to lead and noise. All of the subjects underwent evaluations including self-reported questionnaires, personal histories, clinical examinations, and laboratory tests to determine the blood lead level and pure tone hearing threshold in a soundproof booth. The level of noise in the lead battery manufacturing factory was measured by sound level meters. Among the exposed workers, a significant association was found between hearing thresholds and log PbB. The hearing threshold rose as the log PbB increased, especially at 2000, 4000 and 6000 Hz. Multiple linear regression was applied to determine the effects of lead and noise relative to auditory ability. In the 4000 and 6000 Hz model of linear regression, age and log transformed blood lead levels (log PbB) were associated significantly with auditory ability along with adjustment of noise levels. When considering the effects of age, noise level, smoking, and alcohol consumption, the log transformed blood lead levels (log PbB) nonetheless remained a statistically significant determinant of auditory ability.
並列摘要
Few epidemiologic studies have been carried out of heavy metals, which have been suggested to be ototoxins in humans, in the environment. Based on these epidemiologic studies, heavy metals such as lead, arsenic and manganese may cause hearing loss in humans and animals. No other metal presents a broader range of problems, from the multiplicity of potential routes of exposure to the spectrum of affected organs and systems, than lead. This cross-sectional study was conducted to examine the relationship among blood lead, noise exposure and auditory ability at a lead battery manufacturing factory. The workers were divided into a lead combined noise-exposed group of 75 workers, and a reference group of 51 persons who were not occupationally exposed to lead and noise. All of the subjects underwent evaluations including self-reported questionnaires, personal histories, clinical examinations, and laboratory tests to determine the blood lead level and pure tone hearing threshold in a soundproof booth. The level of noise in the lead battery manufacturing factory was measured by sound level meters. Among the exposed workers, a significant association was found between hearing thresholds and log PbB. The hearing threshold rose as the log PbB increased, especially at 2000, 4000 and 6000 Hz. Multiple linear regression was applied to determine the effects of lead and noise relative to auditory ability. In the 4000 and 6000 Hz model of linear regression, age and log transformed blood lead levels (log PbB) were associated significantly with auditory ability along with adjustment of noise levels. When considering the effects of age, noise level, smoking, and alcohol consumption, the log transformed blood lead levels (log PbB) nonetheless remained a statistically significant determinant of auditory ability.