A 58-year-old female patient who was diagnosed with generalized chronic periodontitis and posterior bite collapse underwent non-surgical periodontal treatment, which was followed by prosthodontic reconstruction. The patient also had diabetes mellitus and type Ⅲ chronic kidney disease. Prior to treatment, among twenty-six teeth, probing depths ranging from 2 mm to 13 mm were found for nineteen teeth. After non-surgical periodontal treatment and provisional prosthesis reconstruction, the probing depth of all teeth was less than 5 mm at the one-year follow-up. Furthermore, there were significant improvements in clinical attachment level for most teeth based on enhanced radiographic bone-like images. In terms of clinical outcome, the patient's periodontium was found to have improved or to be stably maintained after interdisciplinary treatment that combined non-surgical periodontal therapy with prosthetic reconstruction.